Hepatitis C virus and peripheral blood mononuclear cell reservoirs Patricia Baré
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus in peripheral blood mononuclear cells.
RNA extracted from plasma and peripheral blood mononuclear cells of patients with chronic hepatitis C were used as the template for reverse transcription followed by double in vitro enzymatic amplification with nested primers. Hepatitis C virus was detected in 14 of 15 (93.3%) plasma specimens and in 8 of 15 (53.3%) peripheral blood mononuclear cell specimens obtained from patients with chronic...
متن کاملComparison of Hepatitis C Genotypes in Plasma and Peripheral Blood Mononuclear Cells (PMBCs) in Hepatitis C-Infected Patients
Abstract Background and Aims: The Hepatitis C Virus (HCV) is essentially hepatotropic but virus compartment has also been found in other important extra hepatic sites. Detection of HCV RNA in extra hepatic reservoirs such as peripheral blood mononuclear cells (PBMCs) is important for determining of disease progression and effective treatment. The present study aimed to determine of differe...
متن کاملHepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection.
BACKGROUND Occult hepatitis C virus (HCV) infection is characterised by the presence of HCV-RNA in the liver in the absence of anti-HCV, and serum viral RNA. Up to 70% of these patients also have HCV-RNA in peripheral blood mononuclear cells (PBMC) but it is not known if HCV is replicating in these cells. AIM We studied possible HCV replication in PBMC of 18 patients with an occult HCV infect...
متن کاملIn vitro infection of human peripheral blood mononuclear cells by GB virus C/Hepatitis G virus.
GB virus C (GBV-C), also known as hepatitis G virus, is a recently discovered flavivirus-like RNA agent with unclear pathogenic implications. To investigate whether human peripheral blood mononuclear cells (PBMC) are susceptible to in vitro GBV-C infection, we have incubated PBMC from four healthy blood donors with a human GBV-C RNA-positive serum. By means of (i) strand-specific reverse transc...
متن کاملDifferences in hepatitis C virus quasispecies composition between liver, peripheral blood mononuclear cells and plasma.
Hepatitis C virus (HCV) exists in vivo as a highly variable mixture of closely related genomes (quasispecies), but the pathogenetic significance of such heterogeneity is still largely unknown. To investigate this issue, we compared the composition of HCV quasispecies found in the liver, peripheral blood mononuclear cells (PBMC) and plasma of ten patients by single-strand conformation polymorphi...
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ژورنال
عنوان ژورنال: World Journal of Hepatology
سال: 2009
ISSN: 1948-5182
DOI: 10.4254/wjh.v1.i1.67